Wear the Auditore cape in each city.
Collect all the Feathers.
Unlock all 20 pieces of Subject 16's video.
Escape the hideout.
Complete DNA Sequence 14.
Get all Hidden Blades, Item Pouches and Armor upgrades for Ezio.
Complete DNA Sequence 11.
Complete DNA Sequence 10.
Complete DNA Sequence 9.
Perform an Air Assassination on a Poisoned NPC.
Discover the Assassin's Tomb inside the Basilica di San Marco.
Reach 80% of your stronghold's total value.
Discover the Assassin's Tomb inside Santa Maria della Visitazione.
Complete DNA Sequence 8.
Kick a Guard while using the Flying Machine.
Sweep 5 guards at once by using a Long Weapon.
Stun 4 guards at once by throwing sand in their face.
Complete DNA Sequence 7.
Buy a Painting from Florence and Venice.
Complete training and reenter the Animus.
Complete DNA Sequence 6.
Tint your clothes with those colors: Wetland Ebony and Wetland Ivory.
Discover the Assassin's Tomb inside the Rocca di Ravaldino fortress.
Complete DNA Sequence 5.
Spend 5000 florins on Courtesans.
Complete your first assassination mission for Lorenzo Il Magnifico.
Kill 10 enemies while remaining in conflict without being hit.
Complete DNA Sequence 4.
Discover the Assassin's Tomb inside the Torre Grossa.
Upgrade a building in the Stronghold.
Discover the Assassin's Tomb inside Santa Maria del Fiore (The Duomo).
Discover the Assassin's Tomb inside the catacombs under Santa Maria Novella.
Perform a Leap of Faith from the Top of Florence's Giotto's Campanile.
Toss more than 300 florins on the ground.
Hide 5 dead bodies in a Bale of Hay.
Defend a woman's honor.
Intercept a Borgia Courrier.
Synchronize 10 View Points.
Complete DNA Sequence 3.
Find the 8 statuettes in Monteriggioni.
Complete DNA Sequence 2.
Win a race against thieves!
Pickpocket 1000 Florins.
Sprint for 100 meters.
Enter the Animus 2.0.
Break out of Abstergo.
Be reborn as Ezio Auditore Da Firenze.
Complete DNA Sequence 1.
Use your Eagle Vision to scan a Glyph in the environment.
Unlock a piece of Subject 16's video.